Regener8 Men’s Health

Since the release of Regener8, our customer feedback has been exactly what we had hoped for and – in sacrificing the quality of modesty – not a total surprise. In its inception we were certain it would be one of our most popular products, so we set out to find a combination of ingredients that were; backed by human clinical trials, used for centuries in Chinese medicine/remedies, and anecdotally supreme amongst bros at the gym.

For example, the first time I heard about Tongkat Ali (Eurycoma Longifolia or LongJack), was in my teens. It was a standard Chest Monday and I was warming up my rotators in the Fitness First stretching area when I was approached by Eddie. He was never a massive guy, so I was surprised when he confessed that he’d been experiencing some prolonged suppression of natural testosterone after a test E cycle, but not so surprised to find out that he had no idea what a PCT was. “But bro” he said “I’ve been taking this Chinese herb [it’s actually Southeast Asian] called Tongkat Ali, and I swear within a week I’m horny as f*** again.” It turns out it wasn’t just the bros at the gym that were having similar experiences with Tongkat Ali.

Years later, an older gentleman at the office I used to work at explained ever so eloquently that he was finally able to “properly give it to [his] wife again” after years of experiencing low libido. It sparked my interest and turned out there were some pretty extensive human trials that were detailing Tongkat Ali’s efficacy as an aphrodisiac and pro-fertility agent (1), as well as its testosterone-enhancing, anti-stress and anti-aging effects (2). There is also some evidence to suggest it may be a potent pro-erectile and anti-estrogen (3).

The research conducted over years, accompanied by real world insight into the needs of athletes, bodybuilders, weekend warriors and middle-aged men, built the foundations upon which ingredients like Tongkat Ali were selected for use in our Regener8. It is an ingredient selection system we have utilised successfully in the formulation of all our products, coupled with effective and clinical doses of course!

Once Regener8 was released at auzsupps.com, we analysed the statistics on the back-end of the website and watched as it climbed the ranks of popularity week-by-week, surpassing juggernauts like RAD-140 (while still unscheduled) and Thermic Effect. This is where we realized; we’re onto something here. Provided below is a list of the 8 ingredient super blend selected in formulating the Regener8 (see what we did there) and the research-based findings on each meticulously selected ingredient.

1. N-Acetyl Cysteine 1000mg: N-Acetyl Cysteine (NAC) is a glutathione precursor that has been shown to help the body synthesize glutathione (4) the body’s master antioxidant. NAC has also been shown to successfully protect the liver from the damaging effects of toxins and other substances that may elevate liver enzymes (5). In fact, NAC was first documented in its capacity to reduce liver hepatotoxicity when given to a patient experiencing an acetaminophen (paracetamol) overdose in 1978 (6).

Findings summary: protects liver + potent antioxidant

2. Tongkat Ali (200:1) 800mg: The benefits of using Tongkat Ali to boost testosterone, fertility and libido, while acting against estrogen, stress and aging have been touched on above, so the remaining significance of the Tongkat used in Regener8 lies in its 200:1 extract. This ratio has been hailed as the most reputable, as most research yielding the best results on test subjects have all been conducted with Tongkat Ali at 200:1.

Findings summary: pro-testosterone + aphrodisiac (libido booster) + pro-fertility + pro-erectile + anti-estrogen + anti-stress + anti aging

3. Saw Palmetto 600mg: Saw palmetto (Serenoa Repens) has been used for centuries in Asia and North America in the treatment of benign prostatic hyperplasia (BHP – enlargement of the prostate), and an early double-blind, placebo-controlled study detailed notable improvement in many symptoms of BPH over placebo when using Saw Palmetto (7). Saw Palmetto has also shown to inhibit the 5α-reductase enzyme that converts testosterone into dihydrotestosterone (DHT) (8). Like dutasteride (which outperformed finasteride in preventing hair loss and inducing hair regrowth) (9), Saw Palmetto has also been shown to have inhibitory effects against both isoforms of the 5α-reductase enzymes (type 1 (5αR1) and type 2 (5αR2)) (10) indicating that Saw Palmetto could share similar properties as dutasteride in preventing hair loss, in addition to preventing/combating other DHT related side effects.

Findings summary: prostate protection + prevention of nasty DHT related side-effects (including hair loss)

4. Shilajit (Fulvic Acid) 500mg: Studies report that Shilajit’s antioxidative properties protect against cellular damage (11), which is often responsible for speeding the aging process in your heart, lungs, liver, and skin. While a beneficial property to possess, Shilajit has been specifically chosen as part of the Regener8 super-blend for its fertility and testosterone boosting benefits. A 2010 study ‘Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia’ documented 60 infertile men who underwent a 90-day treatment of Shilajit, the results of which were quite promising. Half of these men showed a significant improvement in terms of total sperm count (61.4% more sperm), sperm motility (37.6% better) and level of testosterone (23.5% increase) (12).

Findings summary: testosterone increase + sperm count increase + sperm motility increase + antioxidant

 5. Panax Ginseng 500mg: Ginseng is often referred to as the King of all herbs, and is found to be a promising agent in improving a true abundance of physiological processes in the body. This was one herb we simply could not look past and felt should be a staple in many sports foods intended to assist general health and well being, particularly in men. To list just a few key benefits associated with Panax Ginseng, it has been shown to; improve cognition, mood and sense of well-being (13), enhance libido and erections (14), and improve sleep quality (15).

Findings summary: cognition increase + mood increase + improvement in quality of life and sense of well being + libido and erection increase + improvement in sleep quality

6. Arimistane (Androsta-3 5-diene-7 17-dione) 100mg: A powerful inhibitor of human aromatase, with properties comparable to those of the most effective aromatase inhibitors (AI’s) available (16), such as aromasin and arimidex. Arimistane is commonly referred to as a ‘suicide inhibitor’ because it binds to the aromatase enzyme and inactivates it (17), which is a preferred method of action when dealing with estrogen suppression. Suicidal inhibition prevents the potential for estrogenic rebound as it binds irreversibly to the aromatase enzyme whereas other non-suicidal inhibitors form covalent, reversible bonds (18). AI’s have also shown to improve testosterone levels in men (19) and selective AI’s have also shown declines in aldosterone and cortisol (20) (the stress hormone commonly known to create catabolism/muscle breakdown).

Findings summary: estrogen prevention + testosterone increase + cortisol decline

7. Laxogenin (5-Alpha Hydroxy Laxogenin) 100mg: Commonly referred to as nature’s Anavar for two significant reasons being; its anabolic/androgenic ratio (21), and belonging to a group of plant based steroids known as brassinosteroids. Oral application of 28-Homobrassinolide (HB – a brassinosteroid often used as a Laxogenin substitute) was shown to trigger selective anabolic responses with negligible androgenic side-effects (22) in a 2011 study. HB was also able to stimulate protein synthesis, inhibit catabolism, increase strength and increase lean body mass (22).  Brassinosteroids have further been studied in their anti-carcinogenic capacities and have been connected with the inhibition of cancer growth (23).

Findings summary: anabolic + anti-catabolic + strength increase + protein synthesis stimulation + lean body mass increase + possible anti cancer properties

8. Acacetin (4’-methoxy-5,7-dihydroxyflavone) 100mg: Acacetin is an anti-aromatase and estrogenic activity blocker that is derived from the Damiana Plant, shown by researchers to be one of the most effective natural substance to block the synthesis of estrogen in the human body (24).

Findings summary: natural-substance-based estrogen prevention

We hope you liked this post and found some of the information and references useful! If you’d like to give Regener8 a go, feel free to use code feelingmanly to receive 10% off your next purchase! Click here to use this discount now.

References:

(1) Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized clinical trial on the use of PHYSTA freeze-dried water extract of Eurycoma longifolia for the improvement of quality of life and sexual well-being in men. Evid Based Complement Alternat Med. 2012; 2012:429268.
(2) Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May; 12(3): 376–380.
(3) Teh CH, Abdulghani M, Morita H, Shiro M, Hussin AH, Chan KL. Comparative X-ray and conformational analysis of a new crystal of 13α,21-dihydroeurycomanone with eurycomanone from Eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay. Planta Med. 2011 Jan;77(2):128-32.
(4) Dringen R, Hirrlinger J. Glutathione pathways in the brain. Biol Chem. 2003 Apr;384(4):505-16.
(5) Wang AL, Wang JP, Wang H, Chen YH, Zhao L, Wang LS, et al. A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice. Hepatol Res. 2006 Mar; 34(3):199-206.
(6) Scalley RD, Conner CS. Acetaminophen poisoning: a case report of the use of acetylcysteine. Am J Hosp Pharm. 1978 Aug;35(8):964-7
(7) Champault G, Patel JC, Bonnard AM. A double-blind trial of an extract of the plant Serenoa repens in benign prostatic hyperplasia. Br J Clin Pharmacol. 1984 Sep; 18(3): 461–462.
(8) Bayne EK, Flanagan J, Einstein M, Ayala J, Chang B, Azzolina B, et al. Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp. Br J Dermatol. 1999 Sep;141(3):481-91.
(9) Gubelin Harcha W, Barboza Martínez J, Tsai TF, Katsuoka K, Kawashima M, Tsuboi R, et al. A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. J Am Acad Dermatol. 2014 Mar;70(3):489-498.
(10) Abe M1, Ito Y, Suzuki A, Onoue S, Noguchi H, Yamada S. Isolation and pharmacological characterization of fatty acids from saw palmetto extract. Anal Sci.  2009 Apr;25(4):553-7.
(11) Shibnath Ghosal, Jawahar Lal, Sushil K. Singh, Gautam Dasgupta, Joydeep Bhaduri, Mita Mukhopadhyay, et al. Mast cell protecting effects of shilajit and its constituents. Phytotherapy Research. 1989 Jan; 3(6).
(12) Biswas TK, Pandit S, Mondal S, Biswas SK, Jana U, Ghosh T, et al. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia. 2010 Feb; 42(1):48-56.
(13) Reay JL, Scholey AB, Kennedy DO. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol. 2010 Aug; 25(6):462-71.
(14) de Andrade E, de Mesquita AA, Claro Jde A, de Andrade PM, Ortiz V, Paranhos M, et al. Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian J Androl. 2007 Mar; 9(2):241-4.
(15) Kitaoka K, Uchida K, Okamoto N, Chikahisa S, Miyazaki T, Takeda E, et al. Fermented ginseng improves the first-night effect in humans. Sleep. 2009 Mar 1; 32(3): 413–421.
(16) Ghosh D, Lo J, Morton D, Valette D, Xi J, Griswold J, et al. Novel aromatase inhibitors by structure-guided design. J Med Chem 2012; 55(19): 8464-8476.
(17) Bethea CL, Reddy AP, Robertson N, Colemen K. Effects of aromatase inhibition and androgen activity on serotonin and behavior in male macaques. Behav Neurosci. 2013 Jun; 127(3): 400–414.
(18) Ligibel JA, Winer EP. Clinical differences among the Aromatase Inhibitors. Clin Cancer Res. 2003 Jan; 9(1 Pt 2): 473S-9S.
(19) de Ronde W. Therapeutic uses of aromatase inhibitors in men. Curr Opin Endocrinol Diabetes Obes. 2007 Jun; 14(3):235-40.
(20) Bhatnagar AS. The discovery and mechanism of action of letrozole.
(21) Syrov VN, Kurmukov AG. Experimental study of the anabolic activity of 6-ketoderivatives of certain natural sapogenins Farmakol Toksikol. 1976 Sep-Oct;39(5):631-5.
(22) Esposito D, KomarnytskyS, Shapses S, Raskin I. Anabolic effect of plant brassinosteroid FASEB J.  2011 Oct; 25(10): 3708–3719.
(23) Steigerová J, Oklešťková J, Levková M, Rárová L, Kolář Z, Strnad M. Brassinosteroids cause cell cycle arrest and apoptosis of human breast cancer cells. Chem Biol Interact. 2010 Dec 5;188(3):487-96.
(24) Zhao J, Dasmahapatra AK, Khan SI, Khan IA. Anti-aromatase activity of the constituents from damiana (Turnera diffusa) J Ethnopharmacol. 2008 Dec 8;120(3):387-93.